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  1. #76
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    Re: Anyone Else Depressed Over this Week?



    I wasn't depressed until I read this thread
    World Domination 3 Points at a Time!




  2. #77

    Re: Anyone Else Depressed Over this Week?

    I think anyone who's life is deeply affected by not being able to watch a bunch of grown men playing a kids game needs to find a better hobby. One that involves more than sitting on a bleacher or couch for three hours at a time. Life goes on...




  3. #78
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    Re: Anyone Else Depressed Over this Week?

    Quote Originally Posted by Kevlar View Post
    I think anyone who's life is deeply affected by not being able to watch a bunch of grown men playing a kids game needs to find a better hobby. One that involves more than sitting on a bleacher or couch for three hours at a time. Life goes on...
    Irony at it's finest. Thanks for the laugh




  4. #79

    Re: Anyone Else Depressed Over this Week?

    Seeing Robert Kraft on the cover of the SI I just got in the mail doesn't help either. I guess he gets the credit for Evans' drop.......




  5. #80
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    Re: Anyone Else Depressed Over this Week?

    Quote Originally Posted by NCRAVEN View Post
    Well documented doesn't mean proven.


    So does crystal meth...
    Well documented means peer reviewed clinical studies showing statistically measurabe improvement in depressed patients.

    The last comment is just silly.




  6. #81
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    Re: Anyone Else Depressed Over this Week?

    Quote Originally Posted by DkBlue View Post
    Well documented means peer reviewed clinical studies showing statistically measurabe improvement in depressed patients.

    The last comment is just silly.
    This is going to be my last comment on this topic since this is the football forum.

    You state well documented, but no one and I mean NO ONE can say it's a certainty.

    I had a cousin who was diagnosed with depression received antidepressants and on the warning label says "may cause suicidal thoughts" (or something to that). How can the solution to a problem also be the cause?

    My point is (which is not coming out the way it's in my head), either my cousin was misdiagnosed or there is no measurable way to say someone is depressed or not, because the meds did not fix the depression but the warning label did come true.




  7. #82
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    Re: Anyone Else Depressed Over this Week?

    Quote Originally Posted by NCRAVEN View Post
    This is going to be my last comment on this topic since this is the football forum.

    You state well documented, but no one and I mean NO ONE can say it's a certainty.

    I had a cousin who was diagnosed with depression received antidepressants and on the warning label says "may cause suicidal thoughts" (or something to that). How can the solution to a problem also be the cause?

    My point is (which is not coming out the way it's in my head), either my cousin was misdiagnosed or there is no measurable way to say someone is depressed or not, because the meds did not fix the depression but the warning label did come true.
    When a drug is studied, a certain percentage of patients will experience side effects. Studies will predict how the drug will act in 10,000 pattents with statistical certainty. They cannot redict how a drug will be have in a given individual.

    Suicide is very common in depressed patients, about one in five.




  8. #83
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    Re: Anyone Else Depressed Over this Week?

    They rarely tell you who the patients are that are clinically studied. They tend to find ways to manipulate the surveys and statistics to suit their purposes. You'll also find it to be no surprise that some of the companies that fund these evaluations, have a financial interest in seeing the results sway to a certain direction.
    "When questioned, the Elders explained that they were in search of magical powers. However, they're actually searching for the whereabouts of a certain ring. This ring is a legendary treasure that long ago was known to exist"




  9. #84
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    Re: Anyone Else Depressed Over this Week?

    Quote Originally Posted by DkBlue View Post
    When a drug is studied, a certain percentage of patients will experience side effects. Studies will predict how the drug will act in 10,000 pattents with statistical certainty. They cannot redict how a drug will be have in a given individual.

    Suicide is very common in depressed patients, about one in five.
    OK I lied, that was not my last post.

    If someone does have depression due to a chemical imbalance, and they are given X drug to balance that, why would they experience side effects instead of having the drug work correctly?

    Does that drug not actually work, or did they not have a chemical imbalance?




  10. #85
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    Re: Anyone Else Depressed Over this Week?

    Quote Originally Posted by The Excellector View Post
    They rarely tell you who the patients are that are clinically studied. They tend to find ways to manipulate the surveys and statistics to suit their purposes. You'll also find it to be no surprise that some of the companies that fund these evaluations, have a financial interest in seeing the results sway to a certain direction.
    The number of patients and their demographics are outlined in a clinical study. You have no basis for your statement that they tend to find ways to manipulate the results and that has been a rare occurence.

    The methodology and results are scrutinized and investigators follow an agreed upon protocol.

    A study is peer reviewed before it is published in a reputable journal. If a study is done at Johns Hopkins it is reviewed by a panel of experts before it is published in the New England Journal of Medicine.

    When a drug is up for approval it is reviewed by a panel of experts who make recommendations to the FDA. The FDA experts then take over. In most cases they will ask for additional data that might require more studies.

    I worked on a drug that was highly recommended by the expert panel. FDA submitted 75 pages of questions that they had constructed.

    Three patients out of 8,000 had what appeared to be allergic reactions. FDA required another year of study before approval. There are no short cuts.

    It now costs close to a billion dollars to bring a new drug to market from the day the patent is filed. The 17 year patent life starts that day.
    Last edited by DkBlue; 02-01-2012 at 04:29 PM.




  11. #86
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    Re: Anyone Else Depressed Over this Week?

    Quote Originally Posted by NCRAVEN View Post
    OK I lied, that was not my last post.

    If someone does have depression due to a chemical imbalance, and they are given X drug to balance that, why would they experience side effects instead of having the drug work correctly?

    Does that drug not actually work, or did they not have a chemical imbalance?
    Depression is thought to be caused by low serotonin, a neurotransmitter in the brain. Anti-depressants stimulate
    serotonin. It is a complex mechanism and does not work the same for all patients. Anti-depressants "wear out."
    The body will sense an overoad of serotonin and downregulate itself so there are less receptors available.

    Usually the patient is changed to a new drug with a different mechanism.

    Not every drug works in every patient.

    Side effects are part of the mechanism. Once you are altering neurotransmitters the brain chemistry goes through a lot of changes. Neurotransmitters are powerful chemicals and can cause many side effects.

    The receptors control other functions in the body such as sexual desire and nausea. These are not the receptors targeted but they are impacted.

    It all goes back to the premise that efficacy can be demonstrated for a certain percentage of patients and the incidence of side effects can be discerned. It is not possible however to say what will happen with any indvidual.




  12. #87

    Re: Anyone Else Depressed Over this Week?

    Quote Originally Posted by DkBlue View Post
    Three patients out of 8,000 had what appeared to be allergic reactions. FDA required another year of study before approal. There are no short cuts.

    It now costs close to a billion dollars to bring a new drug to market from the day the patent is filed. The 17 year patent life starts that day.
    That's very depressing.

    During your studies did you ever drop the ball, or have it slapped away because you lost focus and relaxed?

    just askin'.
    If you break the rules you can't make the rules.
    - Remove Coach Tomlin from the NFL Competition committee.




  13. #88
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    Re: Anyone Else Depressed Over this Week?

    Quote Originally Posted by Real Fan Dan View Post
    That's very depressing.

    During your studies did you ever drop the ball, or have it slapped away because you lost focus and relaxed?

    just askin'.
    I was on the company end as a project director. The medical people rarely make mistakes and it usually consists of allowing patients into the study with pre-existing conditions that may skew the results.

    There are study monitors who work with the researchers that monitor everything and also the ethics committee at the hospital has to approve all studies or any changes.

    Drugs are initially studied in healthy volunteers, usually med students or interns to determine does range, toxicity, and all the basics. Once you get sick people into a study things can change. Drugs act differently in different age groups and also differently in different ethnic groups.


    Studies are often discontinued if something adverse comes up and on the other side of the coin, they are shortened if the results are so good they want to make it available to patients.

    Bottom line is drugs are not as exact as the public might think. Some are not well understood. Aspirin for example could not get on the market under today's FDA. Not a chance.




  14. #89
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    Re: Anyone Else Depressed Over this Week?

    Might have to move this soon, but since it's the off season (ugh) I suppose we can let this go for a while ....

    So let me get this straight. Some of you feel that the science of creating medicine assisting the brains function is all a sham even though that same science has been producing medications that assist the function of the body's other organs?

    And you really want to be taken seriously on this?

    Oprah has a couch y'all can jump up and down on.
    WARNING: This post may contain material offensive to those who lack wit, humor, common sense and/or supporting factual or anecdotal evidence. All statements and assertions contained herein may be subject to literary devices not limited to: irony, metaphor, allusion and dripping sarcasm.




  15. #90
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    Re: Anyone Else Depressed Over this Week?

    Quote Originally Posted by HoustonRaven View Post
    Might have to move this soon, but since it's the off season (ugh) I suppose we can let this go for a while ....

    So let me get this straight. Some of you feel that the science of creating medicine assisting the brains function is all a sham even though that same science has been producing medications that assist the function of the body's other organs?

    And you really want to be taken seriously on this?

    Oprah has a couch y'all can jump up and down on.
    For the record, I am not debating this aspect of it.

    I am debating whether depression... or the cause if it is scientifically proven.




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